Understanding the potential side effects of the dengue vaccine is a key step in making an informed health decision. Knowing what to expect after your shot—from common, mild reactions to rare ones—provides peace of mind and empowers you to act confidently. This guide offers a clear and transparent overview based on clinical data.

How Your Body Responds: Why Side Effects Happen
It’s helpful to remember that mild side effects are often a positive sign. They indicate that your immune system is responding to the vaccine, learning to recognize the weakened virus, and building up the protective antibodies that will keep you safe from a future infection. It’s a sign that the vaccine is doing its job.
Common and Mild Side Effects (The “Normal” Response)
The vast majority of side effects from the dengue vaccine are mild and resolve on their own within a few days. Based on clinical studies, the most common reactions include:
- Injection site reactions: This is the most frequent side effect. You might experience some pain, redness, or slight swelling on the arm where you received the shot.
- Headache: A mild to moderate headache is a common systemic reaction.
- Muscle pain (myalgia): Similar to how you might feel after a flu shot, some general muscle achiness is possible.
- General feeling of being unwell (malaise): You might feel a bit tired or “off” for a day or two as your immune system gets to work.
- Low-grade fever: A slight increase in temperature can also occur.
These reactions typically appear within a couple of days of the vaccination and are a normal part of your body’s immune response.
How to Manage Mild Side Effects at Home

If you experience any of these common side effects, they can usually be easily managed at home.
- For pain at the injection site, a cool compress can provide relief.
- For headaches, muscle pain, or fever, you can take Paracetamol as directed.
- Be sure to rest and drink plenty of fluids.
For more comprehensive information on the vaccine, you can always refer to our complete guide to the dengue vaccine.
Rare Side Effects: When to Contact a Doctor
Severe reactions to the dengue vaccine are very rare. Patient safety is always the top priority, which is why a consultation is required to determine if you are the ideal candidate for the dengue vaccine. However, it is important to know what to look for after your shot. According to health authorities like the European Medicines Agency (EMA), which has approved the QDENGA vaccine, you should contact a doctor immediately if you experience:
- Signs of a severe allergic reaction (anaphylaxis): This occurs within minutes to hours of the vaccination and includes symptoms like difficulty breathing, swelling of the face or throat, a rapid heartbeat, or severe dizziness. This is a medical emergency.
- A very high or persistent fever: A fever that lasts for more than 3 days or is unusually high.
- Any other severe or concerning symptoms that do not resolve on their own.
Conclusion: Making an Informed and Confident Decision
For the overwhelming majority of people, the side effects of the dengue vaccine are mild, short-lived, and a clear sign that their body is building powerful protection. Understanding what is normal allows you to make an informed and confident decision about your health. By choosing to vaccinate, you are taking a proactive and science-backed step toward a safer life in Bali, free from the serious risks of dengue fever.
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Our medical team is ready to discuss the benefits and safety profile of the dengue vaccine with you in detail. Book a consultation to get personalized advice and make an informed decision for your health.
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Frequently Asked Questions (FAQ)
How long does the arm soreness last after the vaccine?
Mild pain, redness, or swelling at the injection site typically lasts for only 1 to 3 days.
Can I take painkillers before my shot to prevent pain?
It’s generally not recommended to take painkillers before vaccination. You can take Paracetamol after the shot if you experience discomfort.
Is it normal to feel really tired after the vaccine?
Yes, feeling tired or having a general sense of malaise is a common systemic reaction and a sign your immune system is responding.
Does the second shot have worse side effects than the first?
Clinical studies show that the side effect profiles for the first and second doses are very similar.
What are the chances of a serious allergic reaction?
Severe allergic reactions (anaphylaxis) to any vaccine are extremely rare. This is why a short observation period at the clinic is recommended after the shot.
Are the side effects worse if I have had dengue before?
The clinical trials for QDENGA showed a similar safety profile for people who had and had not been infected with dengue previously.
Can the vaccine cause an allergic reaction?
As with any medicine or vaccine, there is a very small risk of an allergic reaction. Inform your doctor of any known severe allergies before vaccination.
What is anaphylaxis?
Anaphylaxis is a severe, rapid-onset allergic reaction characterized by symptoms like difficulty breathing, swelling of the throat, and a drop in blood pressure. It is a medical emergency but is very rare.
I have a mild cold. Can I still get the vaccine?
It’s generally best to postpone your vaccination until you have fully recovered from any acute illness, even a mild cold.
Do I need to take time off work after the vaccine?
Most people do not need to. The side effects are typically mild enough that you can continue with your normal daily activities.